Genetic Testing for Hereditary Cancers

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The benefits of genetic testing can help you make more informed decisions about options for early cancer detection and risk reduction. Even if you’ve already been diagnosed with cancer, genetic testing can provide important information about your risk for a second cancer, helping you and your doctor determine the most effective medical management strategy for you.

Genetic testing also provides important information to your family members, such as inherited gene mutations that increase the risk for cancer and the chance your parents, brothers and sisters or children might have these mutations, too.

Hereditary Breast and Ovarian Cancer

Red Flags

  • Personal or family history of breast or ovarian cancer before age 50
  • Personal or family history of ovarian cancer at any age
  • Family history of two or more primary diagnoses of breast and/or ovarian cancer
  • Personal or family history of male breast cancer
  • Relatives of patients with a confirmed BRCA-1 or BRCA-2 gene mutation
  • Ashkenazi Jewish descent

The Genetic Test for Breast and Ovarian Cancer

BRACAnalysis® is a genetic test for hereditary breast and ovarian cancer and assesses a woman’s risk for developing these cancers. This simple blood test, which detects mutations in the BRCA1 and BRCA2 genes, has become the standard of care in identifying individuals with hereditary breast and ovarian cancer.

Hereditary Colorectal Cancer

Red Flags:

  • Personal or family history of HNPCC, or hereditary nonpolyposis colorectal cancer; FAP, or familial adenomatous polyposis; AFAP, attenuated familial adenomatous polyposis; or MAP, or MYH -associated polyposis
  • Personal or family history of early-onset (before age 50) colorectal and/or endometrial (uterine) cancer, as well as other related cancers such as: ovarian, stomach, kidney/urinary tract, brain, biliary tract, pancreas, small bowel, and sebaceous adenomas
  • Relatives of patients with a confirmed MLH1, MSH2, or MSH6 gene mutation

The Genetic Test for Colorectal and Abdominal Cancers

COLARIS® is a genetic test for hereditary colorectal and endometrial cancer (hereditary nonpolyposis colorectal cancer, HNPCC). COLARIS® detects disease-causing mutations in three genes, MLH1, MSH2 and MSH6, responsible for the majority of HNPCC.

Hereditary Melanoma

Red Flags:

  • Two or more melanoma diagnoses in an individual or family
  • Melanoma and pancreatic cancer in an individual or family
  • Relatives of patients with a confirmed p16 gene mutation

The Genetic Test for Melanoma

MELARIS® is a genetic test for hereditary melanoma. This test detects inherited mutations in the p16 gene (also called CDKN2A or INK4A), occurring in up to 40 percent of families with hereditary melanoma. Patient survival is excellent when melanoma is detected at an early stage.